OUR SCIENCE
NeuraClick’s CycliClickTM platform uses AI/ML-driven macrocyclic chemistry to harness the power of our own body’s natural peptide-receptor system to accelerate the development of a cure for human mental illnesses.
OUR TECHNOLOGY
Hydrocarbon-stapling
1. Double chain peptide
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- Costly synthesis
- Poor delivery across the brain
2. Single B-chain peptide
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- Poor binding & potency
- Rapid metabolism
3. Stapled peptide
- High-affinity binding & potency
- High stability
- High specificity
- Inexpensive synthesis
- Highly amenable for cellular uptake
A stapled peptide is a modified peptide (peptidomimetic), typically in an alpha-helical conformation, that is constrained by a synthetic brace (“staple”). The staple is formed by a covalent linkage (”click”) between two amino acid side-chains, forming a peptide macrocycle.
Stapled peptide offer enhanced stability, cellular permeability, superior binding affinity and potency through the protein-protein interactions, present varied functionalities encompassing agonism, antagonism, dual-agonism, and exhibit potential in the treatment of variety of central and peripheral disorders.
OUR VALUE PROPOSITION
- Safer endogenous peptide
- Dual targeting (eating and mental health)
- Faster clinical onset of action
- Great receptor affinity and specificity
- High blood-brain-barrier permeability
- Dual-action to multitarget directed ligands
- Increased drug half life
- Efficacious single dose treatment
- Targeted brain delivery
- Minimized side-effects
- Faster FDA approval
- Highly cost-effective (synthesis & delivery)
- Low out-of-pocket cost
- Possibility of insurance coverage
